产品货号：
Z36329
中文名称：
PRKAR1A抗体
英文名称：
Anti-PRKAR1A Antibody (Clone#OTI6C7)
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PRKAR1A Antibody (Clone#OTI6C7) |
| 指标别名 | CAR;CNC;CNC1;PKR1;PPNAD1;PRKAR1;PRKAR1A;Tissue specific extinguisher 1;TSE1 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IF |
| 基因名称 | PRKAR1A |
| 克隆号 | OTI6C7 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG1 |
| 免疫原 | Full-length protein expressed in 293T cell transfected with human PRKAR1A expression vector |
| 实际分子量 | 43.0KD |
| 成分 | PBS (pH7.3) containing 1% BSA,50% glycerol and 0.02% sodium azide. |
| 纯化方式 | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | Stable for 12 months from date of receipt.Store at -20℃ as received. |
| 背景资料 | cAMP is a signaling molecule important for a variety of cellular functions.cAMP exerts its effects by activating the cAMP-dependent protein kinase,which transduces the signal through phosphorylation of different target proteins.The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits.cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.Four different regulatory subunits and three catalytic subunits have been identified in humans.This gene encodes one of the regulatory subunits.This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids.Mutations in this gene cause Carney complex (CNC).This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2.A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40).Three alternatively spliced transcript variants encoding the same protein have been observed. |
| Uniprot ID | P10644 |
| 推荐稀释比 | Western blot (WB) 1:2000 Immunohistochemistry in paraffin section (IHC) 1:50 Immunofluorescence (IF) 1:100 |
相关搜索：PRKAR1A抗体，PRKAR1A单抗，Anti-PRKAR1A Antibody (Clone#OTI6C7)